United have gained the upper hand on rivals Manchester City in the title race, taking top place after defeating West Brom while Roberto Mancini's side slipped up at Swansea.
Terry Connor's Wolves meanwhile are in deep relegation trouble and will need a colossal effort against the leaders to help their survival cause.
They will be hoping to repeat last season's effort in which they stunned United 2-1 at home.
But to do so Wolves will have to overcome their reticence in front of goal. The Midlands club have played 204 minutes since their last score, an equaliser in the thrilling 2-2 comeback draw with Newcastle.
Wolves have netted in each of their past four contests with Sir Alex Ferguson's men, so a free-flowing game could unfold.
After the United test, the Molineux outfit's run home sees them play three of the top four sides, while tricky away trips to Sunderland and Swansea also await.
In selection news, Karl Henry has failed to pull up after a hamstring strain, while fellow midfielder Stephen Hunt is facing a fitness test before the clash.
Defender Sebastien Bassong looks set to miss following a knock to his ankle, while Nenad Milijas is in doubt after sustaining a calf strain in training.
United have an extensive injury list, with Chris Smalling (head), Anders Lindegaard (ankle), Darren Fletcher (bowel), Nemanja Vidic (knee), Michael Owen (thigh), Antonio Valencia (hamstring) and Nani (knock) all sidelined.
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